Epitalon
Longevity Research only Human trials
Also called Epithalon, AEDG peptide
A four-amino-acid synthetic peptide developed in Russia from a pineal gland extract called epithalamin. It is studied for switching on telomerase, the enzyme that maintains chromosome ends, and for effects on melatonin release. Rodent studies reported longer lifespans.
Why people take it
What studies report
- Longer lifespan and fewer tumours in mice and rats
- Telomerase activation and telomere lengthening in human cell cultures
- Restored melatonin rhythm in older monkeys and people in Russian studies
How it works
The synthetic tetrapeptide (Ala-Glu-Asp-Gly) matching the active sequence of the natural pineal complex. Reported to activate telomerase and restore melatonin rhythm.
In practice Unapproved use
- Taken as short pulsed courses, typically 10–20 days once or twice a year, rather than continuously
- Treated in longevity circles as an annual 'reset' instead of a daily supplement
- Frequently paired with the organ bioregulators
Science hasn't caught up: Pulsed annual dosing is near-universal practice, but it comes from the developer's protocols rather than from dose-finding studies.
Reported real-world use, not evidence and not a recommendation.
Worth knowing: Long-term human studies come from a single Russian group and have not been replicated independently.
Status: Mostly animal and cell data, plus small Russian human studies. Not approved.
- Route
- Subcutaneous injection, or oral in the capsule bioregulator form
- Sequence
- Ala-Glu-Asp-Gly
- Formula
- C14H22N4O9
- Molecular weight
- 390.35 g/mol
- CAS
- 307297-39-8
- Available as
- 10 mg, 50 mg
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.