FOXO4-DRI
Longevity Research only Animal studies
Also called FOX-04, Proxofim
A synthetic peptide built from mirror-image amino acids in reverse order, which makes it resistant to breakdown. It blocks the FOXO4 protein from holding on to p53 inside senescent ('worn-out') cells, which pushes those cells to self-destruct. In aged mice this improved fur, kidney function and activity.
Why people take it
What studies report
- Cleared senescent cells in aged mice
- Restored fur density, kidney function and running capacity in old mice
In practice Unapproved use
- Used in senolytic experimentation, typically as short infrequent courses
Science hasn't caught up: A handful of self-experimenters are using a compound whose entire evidence base is one mouse study.
Reported real-world use, not evidence and not a recommendation.
Worth knowing: A single landmark 2017 mouse study plus follow-ups. Nothing in humans.
Status: Animal and cell research only.
- Route
- Subcutaneous injection, from reconstituted lyophilised powder
- Available as
- 2 mg
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.