Humanin (HNG)
Longevity Research only Animal studies
Also called S14G-Humanin, HNG
Humanin is a small peptide encoded in mitochondrial DNA that protects cells from programmed death, in part by blocking the Bax protein. HNG is a version with one amino acid changed (serine 14 to glycine) that is far more potent. It is studied for protecting neurons, heart muscle, retina and blood vessel lining.
Why people take it
What studies report
- Protected neurons from amyloid toxicity in cell and mouse models
- Improved insulin sensitivity in rodents
- Higher natural levels associated with longer life in centenarian studies
In practice Unapproved use
- A niche longevity-community compound, limited by cost and availability
Reported real-world use, not evidence and not a recommendation.
Worth knowing: The association in people is observational. HNG itself has no human trials.
Status: Cell and animal research only.
- Route
- Subcutaneous injection, from reconstituted lyophilised powder
- Sequence
- Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
- CAS
- 330936-70-4
- Available as
- 10 mg
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.