Ipamorelin
Growth hormone In trials Human trials
A five-amino-acid peptide that activates the ghrelin receptor to release growth hormone. It is known for selectivity: in studies it raised growth hormone without meaningfully changing cortisol, prolactin or ACTH, and with little effect on appetite.
Why people take it
What studies report
- Clean growth hormone release without raising cortisol, prolactin or ACTH in human studies
- Studied for restarting bowel movement after abdominal surgery
How it works
Binds the pituitary ghrelin receptor to trigger pulsatile growth hormone release, with notably little effect on cortisol, prolactin or appetite.
In practice Unapproved use
- Typically taken at night to mimic the body's natural growth hormone pulse
- Very commonly stacked with CJC-1295 — the pairing is close to a default
- Preferred over GHRP-2 and GHRP-6 by people who dislike hunger and cortisol effects
Reported real-world use, not evidence and not a recommendation.
Worth knowing: The phase 2 bowel trials did not meet their endpoint and development stopped.
Status: Reached phase 2 trials for post-surgery bowel recovery, then was dropped. Not approved.
- Route
- Subcutaneous injection, from reconstituted lyophilised powder
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2
- Formula
- C38H49N9O5
- Molecular weight
- 711.9 g/mol
- CAS
- 170851-70-4
- Available as
- 5 mg
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.