NAD+
Longevity Supplement / supply Human trials
Also called Nicotinamide adenine dinucleotide
Not a peptide. A coenzyme present in every living cell that carries electrons in the reactions that turn food into energy. It is also consumed by sirtuins and PARP enzymes, which handle DNA repair and gene regulation. Levels decline with age, which drives interest in restoring them.
Why people take it
What studies report
- Central to energy metabolism and DNA repair, well established
- Precursor supplements (NR, NMN) reliably raise blood NAD+ in human trials
- Benefits on strength, metabolism and aging markers have been small or absent in those trials
In practice Unapproved use
- IV infusions in longevity and wellness clinics, often multi-hour and expensive
- Subcutaneous injection at home as a cheaper alternative to clinic IVs
- Oral NR and NMN precursors are the mainstream route
- Widely used for jet lag, hangovers and general fatigue
Science hasn't caught up: Clinic IV NAD+ is a substantial industry built on evidence that has repeatedly failed to show benefit in people who are not deficient.
Reported real-world use, not evidence and not a recommendation.
Worth knowing: Raising NAD+ is easy; showing it does something useful has not been achieved. IV NAD+ is unstudied and expensive.
Status: Sold as a supplement and in infusion clinics. Human evidence for anti-aging benefit is still limited.
- Route
- IV infusion, subcutaneous injection, or oral NR/NMN precursors
- Formula
- C21H27N7O14P2
- Molecular weight
- 663.4 g/mol
- CAS
- 53-84-9
- Available as
- 500 mg
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.