PE-22-28

Cognitive & neuro Research only Animal studies only

Also called Spadin analogue

A seven-amino-acid peptide designed from the breakdown products of spadin, a longer peptide that acts as a fast antidepressant in animals. It blocks TREK-1, a potassium channel in neurons that appears to set the pace of antidepressant response.

Evidence at a glance

Evidence: Animal studies — Not yet studied in people
Status: Research compound only
Dosing: No human study has set a dose

Mouse behavioural models only. No human has been given this peptide in a published trial, and antidepressant effects in mice have a poor record of translating.

What studies report

Blocks the TREK-1 potassium channel, with higher affinity and longer action than spadin itself in mouse work
Antidepressant-like behaviour in mice within days rather than the weeks conventional drugs take
More neurogenesis and more synapse formation in mouse hippocampus

How it works

Blocks TREK-1, a two-pore potassium channel. Mice bred without TREK-1 are resistant to depression-like states, which is the reasoning behind blocking it chemically. Blocking it also appears to increase the birth of new neurons.

Binds a receptor on the cell surface and signals inward

Where it acts

Brain

The library groups this compound under Cognitive & neuro. The diagram shows that target, not every tissue it reaches.

Illustrated

A neuron membrane in close-up with a single generic ion channel spanning the lipid bilayer, conceptual cell biology rather than an exact molecular structure.

AI-generated subject illustration; not a depiction of the compound or evidence of its effects.

Why people take it

DepressionMoodNeurogenesisAnxiety

Reasons people seek it out — not a list of proven effects.

In practice Unapproved use

Occasionally used intranasally for mood by people already using Semax and Selank
Very thin community presence compared with the other neuro peptides here

Science hasn't caught up: There is no human dosing experience to draw on at all, and the compound targets a channel involved in mood regulation.

Reported real-world use, not evidence and not a recommendation.

Status: Preclinical research compound. Not approved anywhere.

Route: Intranasal or subcutaneous injection in reported use
Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg
Molecular weight: 773.9 g/mol
Available as: 5 mg, 10 mg

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Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.