SNAP-8
Skin & hair Research only Human trials
Also called Acetyl octapeptide-3, Acetyl glutamyl heptapeptide-1
An eight-amino-acid cosmetic peptide extended from Argireline. It interferes with the SNARE protein complex that nerve endings use to release acetylcholine, softening the muscle contractions that etch expression lines — the same pathway botulinum toxin blocks, far more weakly and from the outside.
Why people take it
What studies report
- Reduced wrinkle depth in manufacturer-run topical studies
- Interferes with SNARE complex formation in cell assays
In practice Unapproved use
- Found in ordinary over-the-counter anti-aging skincare
Reported real-world use, not evidence and not a recommendation.
Worth knowing: Most of the efficacy data comes from the companies selling it, and a large peptide struggles to penetrate skin to reach nerve endings at all. Effects, where present, are modest.
Status: Used in topical cosmetics. Not a medicine.
- Route
- Topical, in cosmetic formulations
- Sequence
- Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
- Available as
- 10 mg
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.