Semax
Cognitive & neuro Approved · Russia Human trials
A seven-amino-acid peptide developed in Russia from a fragment of the hormone ACTH, with a Pro-Gly-Pro tail added for stability. It has none of ACTH's hormonal activity. It raises BDNF in the brain and is studied for stroke recovery, attention and memory.
Why people take it
What studies report
- Improved recovery after ischemic stroke in Russian trials
- Better attention, memory and mental stamina in healthy volunteers and students
- Raises BDNF in the brain
In practice Off-label
- A nootropic-community staple, usually as a nasal spray
- Used during cognitively demanding periods — exam seasons, deadlines — then stopped
- Commonly cycled rather than taken continuously
Reported real-world use, not evidence and not a recommendation.
Worth knowing: Same caveat: approved and studied almost entirely in Russia, with limited Western replication.
Status: Approved in Russia as a nasal medicine for stroke and cognitive disorders. Not approved elsewhere.
- Route
- Intranasal spray
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- Formula
- C37H51N9O10S
- Molecular weight
- 813.9 g/mol
- CAS
- 80714-61-0
- Available as
- 10 mg
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.