Sermorelin
Growth hormone Approved · US (withdrawn) Human trials
Also called GRF (1-29), Geref
The first 29 amino acids of growth-hormone-releasing hormone, the shortest piece that keeps full activity. It prompts the pituitary to make and release its own growth hormone, so the body's normal feedback controls stay in place. It has a short half-life of minutes.
Why people take it
What studies report
- Stimulates the body's own growth hormone with normal feedback intact
- Used diagnostically to test pituitary function
- Older studies reported improved sleep and body composition in adults
In practice Off-label
- The growth hormone peptide most often prescribed through anti-aging and wellness clinics
- Taken nightly, which suits its very short half-life
Reported real-world use, not evidence and not a recommendation.
Worth knowing: The branded drug was discontinued for commercial reasons, not safety. Effects are modest compared with growth hormone itself.
Status: Formerly FDA-approved (Geref) for childhood growth hormone deficiency; the brand was discontinued for commercial reasons.
- Route
- Subcutaneous injection, from reconstituted lyophilised powder
- Sequence
- Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
- Formula
- C149H246N44O42S
- Molecular weight
- 3357.9 g/mol
- CAS
- 86168-78-7
- Available as
- 5 mg
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.