Klotho (α-Klotho)
Longevity Research only Animal studies
Also called alphaKlothoLR, Anti-aging protein
A large protein named after the Greek fate who spins the thread of life. Mice that cannot make it age rapidly and die early; mice that overproduce it live substantially longer. In people, higher natural levels track with better kidney function and sharper cognition into old age.
Why people take it
What studies report
- Overexpression extended lifespan roughly 20–30% in mice
- Injected klotho improved cognition in old mice and in a small monkey study
- Higher circulating levels associated with better cognition and kidney function in people
In practice Unapproved use
- Barely obtainable; interest is far ahead of any practical access
Reported real-world use, not evidence and not a recommendation.
Worth knowing: The human evidence is observational — people with more klotho do better, which is not the same as showing that giving klotho helps. It is a large protein, so delivery is a genuine unsolved problem.
Status: Research protein. No human trials of administration.
- Route
- Injection, in research settings only
- Molecular weight
- ≈133–135 kDa (long-release construct)
- Available as
- 20 mcg
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.